Gene function prediction from synthetic lethality networks via ranking on demand
نویسندگان
چکیده
منابع مشابه
Gene function prediction from synthetic lethality networks via ranking on demand
MOTIVATION Synthetic lethal interactions represent pairs of genes whose individual mutations are not lethal, while the double mutation of both genes does incur lethality. Several studies have shown a correlation between functional similarity of genes and their distances in networks based on synthetic lethal interactions. However, there is a lack of algorithms for predicting gene function from s...
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Gene function has been a subject of interest but it is far from fully understood. It is known that some genes have certain functions but it is not clear whether those are all the functions they have. It is a recent trend to use different means to predict gene functions; one of them is to use computational methods on large data sets. Different types of information are used in computational metho...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2010
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btq053